Pyoderma gangrenosum and spinal epidural abscess after subcutaneous administration of recombinant human erythropoietin

Pyoderma gangrenosum and spinal epidural abscess after subcutaneous administration of recombinant human erythropoietin.

the right upper arm, lower back, left thigh, and both Pyoderma gangrenosum is an uncommon nonankles. Five days earlier rHuEpo has been administered contagious condition of unknown aetiology resembling by s.c. injection on the lateral aspect of the right upper a Shwartzman-like hypersensitivity reaction. It typicarm. One day after injection, high fever and multiple ally begins as a pustule and p...

Subcutaneous versus intravenous recombinant human erythropoietin administration in hemodialysis patients.

Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous administration in rats.

The pharmacokinetics (PK) and pharmacodynamics (PD) of recombinant human erythropoietin (rHuEPO) were studied in rats after single i.v. and s.c. administration at three dose levels (450, 1350, and 4050 IU/kg). The plasma concentrations of rHuEPO and its erythropoietic effects including reticulocyte (RET), red blood cell (RBC), and hemoglobin (Hb) levels were determined. A two-compartment model ...

Pyoderma Gangrenosum after Augmentation Mammoplasty

A 43-year-old woman with an unremarkable previous medical history underwent a bilateral mammoplasty augmentation with silicone prostheses. Five days later, she developed small ulcers with pustules on the surgical wound, which progressed in periphery to affect the whole breasts, with a necrotic base, ®brin deposition and raised, thickened edges. The lesions were symmetrical and the areolas were ...

Spinal epidural abscess.

BACKGROUND Spinal epidural abscess is an uncommon disease with a relatively high rate of associated morbidity and mortality. The most important determinant of outcome is early diagnosis and initiation of appropriate treatment. OBJECTIVES We aim to highlight the clinical manifestations, describe the early diagnostic evaluation, and outline the treatment principles for spinal epidural abscess i...